Bin Han, PhD
Director of Shanghai Institute of Plant Physiology and Ecology, CAS
Member of CAS
Dr. Bin Han received his PhD at the John Innes Centre-The Sainsbury Laboratory in 1992. He was elected a Member of the Chinese Academy of Sciences (CAS) in 2013. He is the director of Shanghai Institute of Plant Physiology and Ecology, CAS, and the director of the CAS Center for Excellence in Molecular Plant Sciences. He is also the co-editor of Molecular Plant, the academic advisor of John Innes Center in the UK and the vice chairman of the Chinese Society of Genetics.
Prof. Han has been working on 1) genome sequencing and transcriptome studies, 2) sequencing-based genotyping and GWAS, 3) domestication studies, and 4) heterosis studies, using rice as crop of interest. He has achieved great success in all these fields. His lab has firstly finished rice chromosome 4 sequence. By using next-generation sequencing technology, he performed high-resolution genotyping, data imputation and whole genome sequencing-based GWA study, and succeeded to identify a substantial number of quantitative trait loci potentially important for rice production and improvement. Furthermore, by extending this technology into the construction of the rice genome-variation map, he unlocked the origin and domesticated process of Asian cultivated rice. The genetic mechanism of heterosis in crops has long been a puzzle despite the fact that heterosis had been discovered more than a century ago and that various genetic models have already been proposed to explain it. By using the same forward genetic and genomic approaches, Han’s group performed large-scale genomic mapping for yield-related traits and heterotic effects in thousands of hybrid rice varieties, and characterized the genomic architecture of heterosis for yield traits in rice, which succeeded to reveal the mechanism behind this biologically and agronomically important phenomenon. Very recently, his lab has demonstrated the extent of genomic variations among rice complex through a rice pan-genome study. These works are among the most notable epoch-making achievements in rice genome research since the elucidation of the whole genome sequence of rice, and he has actually published many papers dealing with these topics in top journals, including Nature, Nature Genetics, Nature Communications, Genome Research, and Plant Cell.