Jia Chen, PhD

Assistant Professor, Principal Investigator

School of Life Science and Technology

ShanghaiTech University

E-mail: chenjia@shanghaitech.edu.cn

Website: http://slst.shanghaitech.edu.cn/english/2017/1110/c730a4928/page.htm

Biography

Dr. Jia Chen obtained his bachelor’s degree at Department of Biochemistry and Molecular Biology, Nankai University in 2002 and then obtained his Ph. D. at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2009. From 2009-2014, Dr. Chen received his postdoctoral training in National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. Since November 2014, Dr. Chen joined ShanghaiTech University as a tenure-track assistant professor, PI in School of Life Sciences and Technology. Chen lab has revealed the mechanism of APOBEC cytidine deaminase-mediated mutagenesis during the repair of CRISPR/Cas9-generated DNA breaks and developed various base editors for different purposes, including enhanced base editors (eBEs) with improved editing precision and efficiency, dCpf1 base editors (dCpf1-BEs) for base editing in A/T-rich regions and hAPOBEC3A base editors (hA3A-BEs) for efficient base editing in G/C rich and/or highly-methylated regions. We will focus on DNA repair-induced mutagenesis, which underlines the precision of gene editing, the development of certain cancers and aging.