李继喜

Professor of physiology and biophysics of School of Life Sciences

Adjunct professor of Huashan Hospital

Fudan University.

Emaillijixi@fudan.edu.cn

Biography

Dr Jixi Li received his PhD in Genetics from Fudan University in 2006 and undertook postdoctoral researches at Caltech, Cornell Medical College, and Harvard Medical School, USA from 2006-2014. He is currently the Chief Scientist of the Key Research and Development Project form MOST, China.

Professor Li’s research focuses on the structural basis and molecular mechanism of cell programmed death (necrosis, pyroptosis), inflammation, and the crosstalk between cell death and neurodegenerative diseases (Alzheimer’s disease and Parkinson’s disease).

Selected Publications:

Chen Y, Liu H, Yang C,Gao Y, Yu X, Chen X, Cui R, Zhen L, Li S, Li X, Ma J, Huang Z, Li J*, Gan J*. Crystal structures and implication of the error-prone DNA ligase of African swine fever virus. Nat Commun. 2019 Jan 23;10(1):387. doi: 10.1038/s41467-019-08296-w.

Mompeán M#, Li W#, Li J#, Laage S, Siemer AB, Bozkurt G, Wu H, Mcdermott A. The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-amyloid Signaling Complex. Cell 2018 May 17;173(5):1244-1253.

Yang C, Wu R, Liu H, Chen Y, Gao Y, Chen X, Li Y, Ma J, Li J*, Gan J*. Structural insights into DNA degradation by human mitochondrial nuclease MGME1. Nucleic Acids Res. 2018 Nov 16;46(20):11075-11088.

Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H*, Li J*, Silverman N*. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling. Immunity 2017 Oct 17;47(4):635-647.

Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW, Li J*. Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.  Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10642-10647.

Yin Q, Fu T, Li J*, Wu H*. Structural Biology of Innate Immunity. Annual Rev Immunol 2015 Mar 21;33:393-416.

Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis. Cell. 2012 Jul 20;150(2):339-50.